### Publication

, , , , , , and Dendritic sodium spikes endow neurons with inverse firing rate response to correlated synaptic activity Journal of Computational Neuroscience, 45(3), 2018 URL, DOI, RIS, BibTex
Many neurons possess dendrites enriched with sodium channels and are capable of generating action potentials. However, the role of dendritic sodium spikes remain unclear. Here, we study computational models of neurons to investigate the functional effects of dendritic spikes. In agreement with previous studies, we found that point neurons or neurons with passive dendrites increase their somatic firing rate in response to the correlation of synaptic bombardment for a wide range of input conditions, i.e. input firing rates, synaptic conductances, or refractory periods. However, neurons with active dendrites show the opposite behavior: for a wide range of conditions the firing rate decreases as a function of correlation. We found this property in three types of models of dendritic excitability: a Hodgkin-Huxley model of dendritic spikes, a model with integrate and fire dendrites, and a discrete-state dendritic model. We conclude that fast dendritic spikes confer much broader computational properties to neurons, sometimes opposite to that of point neurons.

### Reference

@article{Górski2018,
author = "T. Górski and R. Veltz and M. Galtier and H. Fragnaud and J. S. Goldman and B. Teleńczuk and A. Destexhe",
title = "Dendritic sodium spikes endow neurons with inverse firing rate response to correlated synaptic activity",
year = 2018,
journal = "Journal of Computational Neuroscience",
volume = 45,
number = 3,
month = "Dec",
doi = "10.1007/s10827-018-0707-7",
url = "https://doi.org/10.1007/s10827-018-0707-7"
}


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